News

23
Aug
Stress results in graying of hairs!

Posted by: Admin

When people are stressed, chemicals are activated which damage DNA and makes people look older and also enhances the risk of diseases, revealed a new study.

Mice were fed adrenalin-like compound to trigger stress which reduces amount of a protein that keeps us healthy by protecting our cells from developing abnormalities.

Professor Robert Lefkowitz, of Duke University, North Carolina, said, "This could give us a plausible explanation of how chronic stress may lead to a variety of human conditions and disorders, which range from merely cosmetic, like greying hair, to life-threatening disorders like malignancies."

The findings of the experiments of the researchers is published in Nature, wherein the scientists discovered mechanism through the scientists have found out a molecular mechanism through which adrenaline act to destroy DNA.

For four weeks, the mice were given compound which resulted in degradation of the protein known as the "guardian of the genome" for its role in preventing cancer.

Prof Lefkowitz said, "We believe this paper is the first to propose a specific mechanism through which a hallmark of chronic stress, elevated adrenaline, could eventually cause DNA damage that is detectable."

The study also revealed that DNA damage was prevented in mice lacking a protein known as beta-arrestin 1.

Loss of it stabilized levels of p53 both in the thymus, an organ that strongly responds to acute or chronic stress, and in the testes where paternal stress might affect an offspring's genome.

Co-researcher Dr Makoto Hara said, "The study showed chronic stress leads to prolonged lowering of p53 levels. We hypothesize this is the reason for the chromosomal irregularities we found in these chronically stressed mice."

 


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